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Remark: Barbiturates may perhaps maximize adverse effects, together with respiratory despair, produced by poisonous doses of TCAs. With therapeutic doses of TCAs, barbiturates enhance metabolism and decrease blood concentrations of TCAs.

Observe Carefully (1)pentobarbital will increase the stage or outcome of clopidogrel by influencing hepatic/intestinal enzyme CYP3A4 metabolism.

pentobarbital will minimize the extent or influence of abiraterone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.

Monitor Carefully (one)pentobarbital will lessen the extent or result of tadalafil by influencing hepatic/intestinal enzyme CYP3A4 metabolism.

Observe Intently (1)pentobarbital will lower the level or impact of osilodrostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

pentobarbital will lower the extent or effect of quetiapine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.

Contraindicated (1)pentobarbital will reduce the extent or effect of lumefantrine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration with powerful CYP3A4 inducers can result in lowered serum concentrations and loss of antimalarial efficacy

pentobarbital will minimize the extent or outcome of nelfinavir by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.

pentobarbital will minimize the level or result of cyclosporine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.

Contraindicated (1)pentobarbital will lessen the level or effect of naloxegol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Usage of naloxegol with more info sturdy CYP3A4 inducers just isn't suggested

pentobarbital will reduce the extent or impact of terbinafine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.

pentobarbital will lower the extent or effect of osilodrostat by influencing hepatic/intestinal enzyme CYP3A4 metabolism.

Coadministration of zuranolone with other CNS depressants may perhaps maximize impairment of psychomotor functionality or CNS depressant effects. If unavoidable, consider dose reduction. .

pentobarbital will lower the level or result of fostemsavir by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.